Physiological concentrations of retinoic acid can induce acute alterations in the expression of the enzyme tissue transglutaminase in cultured macrophages. The induction of this enzyme offers a probe to study the mechanism of retinoid action in both normal and leukemic cells.

It would be generally accepted that G. E. Moore’s celebrated “Refutation of Idealism,” set forth at the turn of the century, constitutes the classic statement of modern realism. The seeming strengths of this position have been elaborated more recently by a notable realist proponent, Don Locke, who, following Moore, takes for granted what is, in effect, the basic assumption of the “Refutation”—the assumption, namely, that each and every variant of the idealist standpoint is embraced under the central Berkeleian (...) contention that “esse is percipi.” It will be my object to argue that the plausibility of Locke’s realism stems from a basic confusion of terms, and that, in its implications, the position becomes vacuous when set in opposition to idealism. (shrink)

Little research has explored the perceptions of military medical providers in the deployed environment and how their perceptions may change over time across an extended military conflict. To our knowledge, no studies have examined military medical providers’ opinions on readiness for their roles in the post-9/11 contingency operations. What has been published indicates that, during the height of Operation Iraqi Freedom, military medical providers often deployed with little notice and minimal formal training. The present report examines data obtained from multiple (...) cohorts of military medical providers (N = 321) deployed to Iraq between 2005 and 2009. Despite varying degrees of support from the U.S. public, our findings indicate that U.S. Air Force military medical providers’ support for the people of Iraq, their belief in the mission, and their ability to influence change did not vary with time. (shrink)

It is raining but you don’t believe that it is raining. Imagine accepting this claim. Then you are committed to saying ‘It is raining but I don’t believe that it is raining’. This would be an ‘absurd’ thing to claim or assert, yet what you say might be true. It might be raining, while at the same time, you are completely ignorant of the state of the weather. But how can it be absurd of you to assert something about yourself (...) that might be true of you? This is Moore’s paradox as it occurs in speech. What is the source of the absurdity? And why does it strike us that a contradiction is somehow at work when there is no contradiction in the content of what is asserted? In Section 2, I describe Moore’s formulation of the paradox and evaluate his own solutions. In Section 3, I discuss Wittgenstein’s inf luence in solving the paradox. In Section 4, I discuss Shoemaker’s priority thesis that once the absurdity in belief has been explained, then this will translate into an explanation of the absurdity in assertion. In Section 5, I discuss work on omissive and commissive Moore-paradoxical assertions, i.e. those of the forms p & I don’t believe that p and p & I believe that not-p. In Section 6, I discuss work on assertions of the form p & I don’t know that p. (shrink)

It is raining but you don’t believe that it is raining. Imagine silently accepting this claim. Then you believe both that it is raining and that you don’t believe that it is raining. This would be an ‘absurd’ thing to believe,yet what you believe might be true. Itmight be raining, while at the same time, you are completely ignorant of the state of the weather. But how can it be absurd of you to believe something about yourself that might be (...) true of you? This is Moore’s paradox as it occurs in thought. Solving the paradox consists in explaining why such beliefs are absurd. I give a survey of some of the main explanations. I largely deal with explanations of the absurdity of ‘omissive’ beliefs with contents of the form p & I don’t believe that p and of ‘commissive beliefs’ with contents of the form p & I believe that not-p as well as beliefs with contents of the form p & I don’t know that p. (shrink)

G. E. Moore observed that to assert, 'I went to the pictures last Tuesday but I don't believe that I did' would be 'absurd'. Over half a century later, such sayings continue to perplex philosophers. In the definitive treatment of the famous paradox, Green and Williams explain its history and relevance and present new essays by leading thinkers in the area.

What can--and what can't--philosophy do? What are its ethical risks--and its possible rewards? How does it differ from science? In Philosophy as a Humanistic Discipline , Bernard Williams addresses these questions and presents a striking vision of philosophy as fundamentally different from science in its aims and methods even though there is still in philosophy "something that counts as getting it right." Written with his distinctive combination of rigor, imagination, depth, and humanism, the book amply demonstrates why Williams was one (...) of the greatest philosophers of the twentieth century. Spanning his career from his first publication to one of his last lectures, the book's previously unpublished or uncollected essays address metaphysics, epistemology, and ethics, as well as the scope and limits of philosophy itself. The essays are unified by Williams's constant concern that philosophy maintain contact with the human problems that animate it in the first place. As the book's editor, A. W. Moore, writes in his introduction, the title essay is "a kind of manifesto for Williams's conception of his own life's work." It is where he most directly asks "what philosophy can and cannot contribute to the project of making sense of things"--answering that what philosophy can best help make sense of is "being human." Philosophy as a Humanistic Discipline is one of three posthumous books by Williams to be published by Princeton University Press. In the Beginning Was the Deed: Realism and Moralism in Political Argument was published in the fall of 2005. The Sense of the Past: Essays in the History of Philosophy is being published shortly after the present volume. (shrink)

What explanation is there of the source of my justification for my beliefs about my beliefs that respects the fact that I am normally the best authority on them? Moore's paradox demands an explanation of the absurdity of believing or asserting possible truths of the forms p but I don't believe that p or p but I believe that not-p. I argue for Evans principle that whatever justifies me in believing that p also justifies me in believing that I (...) believe that p. This helps explain how I come to know my own beliefs and also shows that it is impossible for a Moorean belief to be justified. I then explain the absurdity of Moorean assertion while avoiding the messy notion of 'expressing belief' yet acknowledging Shoemaker’s constraint that if I cannot non-absurdly believe that p then I cannot non-absurdly assert that p. (shrink)

I give an account of the absurdity of Moorean beliefs of the omissive form(om) p and I don’t believe that p,and the commissive form(com) p and I believe that not-p,from which I extract a definition of Moorean absurdity. I then argue for an account of the absurdity of Moorean assertion. After neutralizing two objections to my whole account, I show that Roy Sorensen’s own account of the absurdity of his ‘iterated cases’(om1) p and I don’t believe that I believe that (...) p,and(com1) p and I believe that I believe that not-p,is unsatisfactory. I explain why it is less absurd to believe or assert (om1) or (com1) than to believe or assert (om) or (com) and show that despite appearances, subsequent iterations of (om1) or (com1) do not decrease the absurdity of believing or asserting them. (shrink)

Jaakko hintikka claims to have explained the (only quasi-Logical) absurdity of (m) "p but I don't believe that p". I argue that, While his explicans (b) is true so far as it goes, It is as badly in need of explanation as is (m) itself. I offer two lines of reasoning designed to account for (b) and further to localize the absurdity of (m); but I do not claim to have given the whole story.

G.E. Moore famously observed that to say, ‘I went to the pictures last Tuesday but I don’t believe that I did’ or ‘I believe that he has gone out, but he has not’. would be ‘absurd’. Moore-paradoxical omissive or commissive beliefs of the forms p & I do not believe that p and p & I believe that not-p. are also absurd, although their contents are possible truths. Can there be ‘Moorean desires’, namely desires of the forms I (...) desire both that and I desire both that that are ‘Moore-paradoxical’, in the sense that they are absurd roughly in the way Moore-paradoxical beliefs are absurd? I argue that the most promising approach to a yes is a normative account of doxastic Moore-paradoxicality that parallels a normative account of Moorean desire. It turns out that this won’t work, not because there are no norms of desire, but because the norms required are ones we should reject. Unlike Moorean belief, which is always irrational, Moorean desire, although often odd, is sometimes sensible. An interesting lesson to be learned along the way—and an important one for functionalism—is that the logic of desire differs from that of both belief and conscious belief. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

What can--and what can't--philosophy do? What are its ethical risks--and its possible rewards? How does it differ from science? In Philosophy as a Humanistic Discipline, Bernard Williams addresses these questions and presents a striking vision of philosophy as fundamentally different from science in its aims and methods even though there is still in philosophy "something that counts as getting it right." Written with his distinctive combination of rigor, imagination, depth, and humanism, the book amply demonstrates why Williams was one of (...) the greatest philosophers of the twentieth century. Spanning his career from his first publication to one of his last lectures, the book's previously unpublished or uncollected essays address metaphysics, epistemology, and ethics, as well as the scope and limits of philosophy itself. The essays are unified by Williams's constant concern that philosophy maintain contact with the human problems that animate it in the first place. As the book's editor, A. W. Moore, writes in his introduction, the title essay is "a kind of manifesto for Williams's conception of his own life's work." It is where he most directly asks "what philosophy can and cannot contribute to the project of making sense of things"--answering that what philosophy can best help make sense of is "being human." Philosophy as a Humanistic Discipline is one of three posthumous books by Williams to be published by Princeton University Press. In the Beginning Was the Deed: Realism and Moralism in Political Argument was published in the fall of 2005. The Sense of the Past: Essays in the History of Philosophy is being published shortly after the present volume. (shrink)

G. E. Moore famously observed that to say, “ I went to the pictures last Tuesday but I don’t believe that I did” would be “absurd”. Why should it be absurd of me to say something about myself that might be true of me? Moore suggested an answer to this, but as I will show, one that fails. Wittgenstein was greatly impressed by Moore’s discovery of a class of absurd but possibly true assertions because he saw that (...) it illuminates “the logic of assertion”. Wittgenstein suggests a promising relation of assertion to belief in terms of the idea that one “expresses belief” that is consistent with the spirit of Moore’s failed attempt to explain the absurdity. Wittgenstein also observes that “under unusual circumstances”, the sentence, “It’s raining but I don’t believe it” could be given “a clear sense”. Why does the absurdity disappear from speech in such cases? Wittgenstein further suggests that analogous absurdity may be found in terms of desire, rather than belief. In what follows I develop an account of Moorean absurdity that, with the exception of Wittgenstein’s last suggestion, is broadly consistent with both Moore’s approach and Wittgenstein’s. (shrink)

One tradition of solving the surprise exam paradox, started by Robert Binkley and continued by Doris Olin, Roy Sorensen and Jelle Gerbrandy, construes surpriseepistemically and relies upon the oddity of propositions akin to G. E. Moore’s paradoxical ‘p and I don’t believe that p.’ Here I argue for an analysis that evolves from Olin’s. My analysis is different from hers or indeed any of those in the tradition because it explicitly recognizes that there are two distinct reductios at work (...) in the student’s paradoxical argument against the teacher. The weak reductio is easy to fault. Its invalidity determines the structure of the strong reductio, so-calledbecause it is more difficult to refute, but ultimately unsound because of reasons associated with Moore-paradoxicality. Previous commentators have not always appreciated this difference, with the result that the strong reductio is not addressed, or the response to the weak reductio is superfl uous. This is one reason why other analyses in the tradition are vulnerable to objections to which mine is not. (shrink)

I argue that Moore's propositions, for example, 'I went to the pictures last Tuesday but I don't believe that I did' cannot be rationally believed. Their assertors either cannot be rationally believed or cannot be believed to be rational. This analysis is extended to Moorean propositions such as God knows that I am an atheist and I believe that this proposition is false. I then defend the following definition of assertion: anyone asserts that p iff that person expresses a (...) belief that p with the intention of causing relevant epistemic change in the cognition of an actual or potential audience. (shrink)

What can--and what can't--philosophy do? What are its ethical risks--and its possible rewards? How does it differ from science? In Philosophy as a Humanistic Discipline, Bernard Williams addresses these questions and presents a striking vision of philosophy as fundamentally different from science in its aims and methods even though there is still in philosophy "something that counts as getting it right." Written with his distinctive combination of rigor, imagination, depth, and humanism, the book amply demonstrates why Williams was one of (...) the greatest philosophers of the twentieth century. Spanning his career from his first publication to one of his last lectures, the book's previously unpublished or uncollected essays address metaphysics, epistemology, and ethics, as well as the scope and limits of philosophy itself. The essays are unified by Williams's constant concern that philosophy maintain contact with the human problems that animate it in the first place. As the book's editor, A. W. Moore, writes in his introduction, the title essay is "a kind of manifesto for Williams's conception of his own life's work." It is where he most directly asks "what philosophy can and cannot contribute to the project of making sense of things"--answering that what philosophy can best help make sense of is "being human." Philosophy as a Humanistic Discipline is one of three posthumous books by Williams to be published by Princeton University Press. In the Beginning Was the Deed: Realism and Moralism in Political Argument was published in the fall of 2005. The Sense of the Past: Essays in the History of Philosophy is being published shortly after the present volume. (shrink)

(A) I went to the pictures last Tuesday but I don’t believe that I did (1942, p. 543) or (B) I believe that he has gone out. But he has not (1944, p. 204) would be “absurd” (1942, p. 543; 1944, p. 204). Wittgenstein’s letters to Moore show that he was intensely interested in this discovery of a class of possibly true yet absurd assertions. Wittgenstein thought that the absurdity is important because it is “something similar to a contradiction, (...) thought it isn’t one” (1974, p. 177). What is the explanation of the absurdity of saying or believing something about myself that might be true? Wittgenstein thought that although the explanation will say “something about the logic of assertion” it will also show that “logic isn’t as simple as logicians think it is”. So although the explanation should.. (shrink)

G. E. Moore observed that to for me to assert, “I went to the pictures last Tuesday but I don’t believe that I did” would be “absurd”. Over half a century later, the explanation of the nature of this absurdity remains problematic. Such assertions are unlike semantically odd Liar-type assertions such as “What I’m now saying is not true” since my Moorean assertion might be true: you may consistently imagine a situation in which I went to the pictures last (...) Tuesday but fail to believe that I did. Moreover, if you contradict my assertion then your words, “If he went to the pictures last Tuesday then he believes he did” do not express a necessary truth1. Nonetheless it remains absurd of me to assert that p and I don’t believe that p. It seems no less absurd of me to silently judge that p and I don’t believe that p2. But why should it be absurd of me to assert something that might be true of me? Why should it be absurd of me to believe something that might be true of me? (shrink)

As scientific and engineering efforts become increasingly global in nature, the need to understand differences in perceptions of research ethics issues across countries and cultures is imperative. However, investigations into the connection between nationality and ethical decision-making in the sciences have largely generated mixed results. In Study 1 of this paper, a measure of biases and compensatory strategies that could influence ethical decisions was administered. Results from this study indicated that graduate students from the United States and international graduate students (...) studying in the US are prone to different biases. Based on these findings, recommendations are made for developing ethics education interventions to target these decision-making biases. In Study 2, we employed an ethics training intervention based on ethical sensemaking and used a well-established measure of ethical decision-making that more fully captures the content of ethical judgment. Similar to Study 1, the results obtained in this study suggest differences do exist between graduate students from the US and international graduate students in ethical decision-making prior to taking the research ethics training. However, similar effects were observed for both groups following the completion of the ethics training intervention. (shrink)

Key to Steve Fuller’s recent defense of intelligent design is the claim that it alone can explain why science is even possible. By contrast, Fuller argues that Darwinian evolutionary theory posits a purposeless universe leaving humans with no motivation to study science and no basis for modifying an underlying reality. I argue that this view represents a retreat from insights about knowledge within Fuller’s own program of social epistemology. I argue for a Darwinian picture of science as a product of (...) cultural evolution building upon biological capabilities and liabilities bequeathed to us by biological evolution. Dual Inheritance or Gene-Culture Coevolution Theory can help us understand how complex social institutions emerged out of distinct, if connected, processes of biological and cultural evolution. Only by understanding how the unnatural nature of modern science emerged through cultural evolution can we consider where modern science functions well or poorly. (shrink)

This book analyzes the support that should be given to minority views, reconsidering classic debates in Science and Technology Studies and examining numerous case studies.

In lieu of an abstract, here is a brief excerpt of the content:IntroductionWilliam T. Myershenning offers a most significant work that deals with fundamental yet neglected subjects in Dewey's philosophy, and she challenges much of the cognitive and linguistic efforts to recast pragmatism as part of the epistemology industry. She does all of this by asking questions that we have not really engaged before.Henning's central argument is that Dewey's theory of mind offers an implicit theory of the unconscious, one that (...) has more in common with psychodynamic understandings of the self than with the cognitive-behaviorism that has become the dominant model for the American mind. This kinship between Dewey and psychodynamic perspectives is found in its rejection of atomistic experience and its emphasis on the felt dimensions of experience. Although the recent revival of interest in Dewey has most often linked him with a more linguistic pragmatism and epistemology, Henning moves away from that trend to re-engage with Dewey's "cultural naturalism," returns to the question of what Dewey means by "experience," and advocates for the value of the non-linguistic, non-cognitive portion therein.It is through Dewey's theory of quality that Henning finds a clear connection to the unconscious. Dewey holds that we live in a qualitative world, that we experience the world as affectively charged, and he claims that things come together only insofar as they are pervaded by a single unifying quality. The process of knowing anything begins first in an immediate, sensuous, and affective experience, a dimension that eludes linguistic symbols. That is, there is an ineffable portion of experience that supports our discursive practices and can never be exhausted by them. Henning holds that insofar as qualities resist language and are immediately and sensuously available, there is also a sense in which they guide and form experience unconsciously. [End Page 75]Having set forth her background and thesis in the first half of the book, Henning then turns to Dewey's conceptions of aesthetic and religious experience, where she finds the best evidence for an implicit proposal for a theory of the unconscious. She starts with Dewey's notion that we are primarily aesthetic creatures. The aesthetic is the realm of human experience that most effectively communicates its qualitative dimension. Henning then demonstrates the nature of the aesthetic unconscious through encounters with art, desire, and the sacred. [End Page 76]William T. MyersBirmingham-Southern CollegeCopyright © 2024 The Board of Trustees of the University of Illinois... (shrink)

This article reports the findings of a survey examining if there are gender and career stage differences between male and female practitioners regarding ethical judgment. The results show that, on average, females adopted a more strict ethical stance than their male counterparts on 7 out of 19 vignettes. Males on the other hand, demonstrated a more ethical stance than their female counterparts on 2 out of 19 vignettes. The results furthermore indicate there is a significant difference in ethical judgment across (...) career stages. Overall, it appears that practitioners in later career stages display higher ethical judgment than practitoners in lower career stages. Implications are provided for both practitioners and academicians. (shrink)

I served as a medical student and resident in the 1960s. Science as a belief system had reached a pinnacle. Yet Not infrequently in those days, I found myself caring, with little available backup, for a hospital ward filled with sick and dying people. It was a lonely and often frightening responsibility. I began to encounter situations that were at odds with our collective certainty that science would provide the answers. Some of these memories I repressed for almost a decade. (...) I was unable to process them until I had personally experienced a more humanistic side of medicine. (shrink)

In _The __Critical Advantage_, noted scholar and early childhood expert William T. Gormley, Jr. takes a wide-ranging look at the important role of critical thinking in preparing students for college, careers, and civic life. Drawing on research from psychology, philosophy, business, political science, neuroscience, and other disciplines, he offers a contemporary definition of critical thinking and its relationship to other forms of thinking, including creative thinking and problem solving. When defined broadly and taught early, he argues, critical thinking is (...) a “potential cure for some of the biggest problems we face as a nation,” including education deficits, employment deficits, and the recent surge of partisanship in democratic politics. While there are encouraging signs—the Common Core State Standards have drawn attention to the importance of critical thinking—recent efforts have been too narrowly focused on improving textual analysis in high school. Those who might benefit the most from curricula prioritizing critical thinking, including disadvantaged students, are less likely to be represented in courses and other activities that encourage this skill. Gormley argues for prioritizing critical thinking skills in PreK–12. He takes readers into innovative classrooms around the country, including schools in Pennsylvania, Oklahoma, and Virginia, and offers specific recommendations for promoting critical thinking and embedding it across the curriculum. _The Critical Advantage_ is an insightful and fascinating account of an intellectual journey culminating in a fresh vision for the future of US schooling. (shrink)

Recent work on Imre Lakatos’s missing Hungarian dissertation on the historical sociology of science sheds new light on his mature philosophy of science. Remembered primarily as an “internalist” defender of the autonomy of science, and a Cold Warrior in poli­tics, commentators have mistaken his contribution as primarily a rearguard action against the followers of Thomas Kuhn and the “externalists” influenced by Boris Hessen. It comes as a surprise, then, to find that he developed and retained a fully general soci­ology of (...) scientific knowledge, with Marxist roots that articulated Lenin’s “inexhaustible atom.” He carried forward this emphasis on the fallible, changing, and incomplete nature of our engagement with the natural world by a dialectical account of how research programs advance and recede historically. In his effort to develop a synthesis of Popper and Kuhn, and via his engagement with Paul Feyerabend, he continued to develop a distinctly dialectical ap­proach to science. (shrink)